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At screening, subjects had normal renal function or RI according to predefined creatinine clearance (CL CR ) criteria using the CockcroftGault formula [31]

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The primary effects of GLP-1 RA involve controlling blood glucose levels in individuals with T2DM by promoting glucose-dependent insulin release [67], inhibiting glucagon production, decreasing hepatic glucose output [68], improving insulin secretion, reducing the apoptosis of -cells, promoting the proliferation of -cells [69] and curbing weight gain [70]

doi: 10.1016/j.biomaterials.2021.121326 101 HisadaRYoshidaNUmedaMBurbanoCBhargavaRScherlingerMet al

Kidney Int 49:18 Hameed W, Avan BI, Feroz AS, Khan B, Fatmi Z, Jafri H, Wassan MA, Siddiqi S (2022) Impact of COVID-19 on mental health of primary healthcare workers in Pakistan: lessons from a qualitative inquiry